Ontology highlight
ABSTRACT:
SUBMITTER: Masri S
PROVIDER: S-EPMC5373476 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Masri Selma S Papagiannakopoulos Thales T Kinouchi Kenichiro K Liu Yu Y Cervantes Marlene M Baldi Pierre P Jacks Tyler T Sassone-Corsi Paolo P
Cell 20160501 4
The circadian clock controls metabolic and physiological processes through finely tuned molecular mechanisms. The clock is remarkably plastic and adapts to exogenous "zeitgebers," such as light and nutrition. How a pathological condition in a given tissue influences systemic circadian homeostasis in other tissues remains an unanswered question of conceptual and biomedical importance. Here, we show that lung adenocarcinoma operates as an endogenous reorganizer of circadian metabolism. High-throug ...[more]