Long-term cerebral white and gray matter changes after preeclampsia.

ABSTRACT:

Objective

To determine whether changes in cerebral structure are present after preeclampsia that may explain increased cerebrovascular risk in these women.

Methods

We conducted a case control study in women between 5 and 15 years after either a preeclamptic or normotensive pregnancy. Brain MRI was performed. Analysis of white matter structure was undertaken using voxel-based segmentation of fluid-attenuation inversion recovery sequences to assess white matter lesion volume and diffusion tensor imaging to measure microstructural integrity. Voxel-based analysis of gray matter volumes was performed with adjustment for skull size.

Results

Thirty-four previously preeclamptic women (aged 42.8 ± 5.1 years) and 49 controls were included. Previously preeclamptic women had redu

SUBMITTER: Siepmann T 

PROVIDER: S-EPMC5373775 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature