Ontology highlight
ABSTRACT:
SUBMITTER: Liang Z
PROVIDER: S-EPMC5373822 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Liang Ziwei Z Brown Karen E KE Carroll Thomas T Taylor Benjamin B Vidal Isabel Ferreirós IF Hendrich Brian B Rueda David D Fisher Amanda G AG Merkenschlager Matthias M
eLife 20170320
Turning genes on and off is essential for development and homeostasis, yet little is known about the sequence and causal role of chromatin state changes during the repression of active genes. This is surprising, as defective gene silencing underlies developmental abnormalities and disease. Here we delineate the sequence and functional contribution of transcriptional repression mechanisms at high temporal resolution. Inducible entry of the NuRD-interacting transcriptional regulator Ikaros into mo ...[more]