Ontology highlight
ABSTRACT:
SUBMITTER: Faridi MH
PROVIDER: S-EPMC5373862 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20170306 4
Genetic variations in the ITGAM gene (encoding CD11b) strongly associate with risk for systemic lupus erythematosus (SLE). Here we have shown that 3 nonsynonymous ITGAM variants that produce defective CD11b associate with elevated levels of type I interferon (IFN-I) in lupus, suggesting a direct link between reduced CD11b activity and the chronically increased inflammatory status in patients. Treatment with the small-molecule CD11b agonist LA1 led to partial integrin activation, reduced IFN-I re ...[more]