Ontology highlight
ABSTRACT:
SUBMITTER: Li N
PROVIDER: S-EPMC5373871 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Li Ni N Xue Wei W Yuan Huairui H Dong Baijun B Ding Yufeng Y Liu Yongfeng Y Jiang Min M Kan Shan S Sun Tongyu T Ren Jiale J Pan Qiang Q Li Xiang X Zhang Peiyuan P Hu Guohong G Wang Yan Y Wang Xiaoming X Li Qintong Q Qin Jun J
The Journal of clinical investigation 20170320 4
Loss of phosphatase and tensin homolog (PTEN) and activation of the PI3K/AKT signaling pathway are hallmarks of prostate cancer (PCa). However, these alterations alone are insufficient for cells to acquire metastatic traits. Here, we have shown that the histone dimethyl transferase WHSC1 critically drives indolent PTEN-null tumors to become metastatic PCa. In a PTEN-null murine PCa model, WHSC1 overexpression in prostate epithelium cooperated with Pten deletion to produce a metastasis-prone tumo ...[more]