Ontology highlight
ABSTRACT:
SUBMITTER: Chua MM
PROVIDER: S-EPMC5374422 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Chua Melissa M J MM Ortega Charina E CE Sheikh Ayesha A Lee Migi M Abdul-Rassoul Hussein H Hartshorn Kevan L KL Dominguez Isabel I
Pharmaceuticals (Basel, Switzerland) 20170128 1
CK2 genes are overexpressed in many human cancers, and most often overexpression is associated with worse prognosis. Site-specific expression in mice leads to cancer development (e.g., breast, lymphoma) indicating the oncogenic nature of CK2. CK2 is involved in many key aspects of cancer including inhibition of apoptosis, modulation of signaling pathways, DNA damage response, and cell cycle regulation. A number of CK2 inhibitors are now available and have been shown to have activity against vari ...[more]