Ontology highlight
ABSTRACT:
SUBMITTER: Colie S
PROVIDER: S-EPMC5374488 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Colié Sandra S Sarroca Sara S Palenzuela Rocío R Garcia Idoia I Matheu Ander A Corpas Rubén R Dotti Carlos G CG Esteban José A JA Sanfeliu Coral C Nebreda Angel R AR
Scientific reports 20170331
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a severe and progressive neuronal loss leading to cognitive dysfunctions. Previous reports, based on the use of chemical inhibitors, have connected the stress kinase p38α to neuroinflammation, neuronal death and synaptic dysfunction. To explore the specific role of neuronal p38α signalling in the appearance of pathological symptoms, we have generated mice that combine expression of the 5XFAD transgenes to induce AD symptom ...[more]