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Neuronal p38? mediates synaptic and cognitive dysfunction in an Alzheimer's mouse model by controlling ?-amyloid production.


ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a severe and progressive neuronal loss leading to cognitive dysfunctions. Previous reports, based on the use of chemical inhibitors, have connected the stress kinase p38? to neuroinflammation, neuronal death and synaptic dysfunction. To explore the specific role of neuronal p38? signalling in the appearance of pathological symptoms, we have generated mice that combine expression of the 5XFAD transgenes to induce AD symptoms with the downregulation of p38? only in neurons (5XFAD/p38??-N). We found that the neuronal-specific deletion of p38? improves the memory loss and long-term potentiation impairment induced by 5XFAD transgenes. Furthermore, 5XFAD/p38??-N mice display reduced amyloid-? accumulation, improved neurogenesis, and important changes in brain cytokine expression compared with 5XFAD mice. Our results implicate neuronal p38? signalling in the synaptic plasticity dysfunction and memory impairment observed in 5XFAD mice, by regulating both amyloid-? deposition in the brain and the relay of this accumulation to mount an inflammatory response, which leads to the cognitive deficits.

SUBMITTER: Colie S 

PROVIDER: S-EPMC5374488 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Neuronal p38α mediates synaptic and cognitive dysfunction in an Alzheimer's mouse model by controlling β-amyloid production.

Colié Sandra S   Sarroca Sara S   Palenzuela Rocío R   Garcia Idoia I   Matheu Ander A   Corpas Rubén R   Dotti Carlos G CG   Esteban José A JA   Sanfeliu Coral C   Nebreda Angel R AR  

Scientific reports 20170331


Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a severe and progressive neuronal loss leading to cognitive dysfunctions. Previous reports, based on the use of chemical inhibitors, have connected the stress kinase p38α to neuroinflammation, neuronal death and synaptic dysfunction. To explore the specific role of neuronal p38α signalling in the appearance of pathological symptoms, we have generated mice that combine expression of the 5XFAD transgenes to induce AD symptom  ...[more]

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