Ontology highlight
ABSTRACT:
SUBMITTER: Chen YJ
PROVIDER: S-EPMC5374502 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Chen Ying-Jiun J YJ Friedman Brad A BA Ha Connie C Durinck Steffen S Liu Jinfeng J Rubenstein John L JL Seshagiri Somasekar S Modrusan Zora Z
Scientific reports 20170331
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major birthplace for CINs, and on MGE-like cells differentiated from embryonic stem cells. Two distinct cell types were identified as proliferating neural progenitors and immature neurons, both of which comprised sub-populations. Although lineage developme ...[more]