Ontology highlight
ABSTRACT:
SUBMITTER: Gameiro I
PROVIDER: S-EPMC5374710 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Gameiro Isabel I Michalska Patrycja P Tenti Giammarco G Cores Ángel Á Buendia Izaskun I Rojo Ana I AI Georgakopoulos Nikolaos D ND Hernández-Guijo Jesús M JM Teresa Ramos María M Wells Geoffrey G López Manuela G MG Cuadrado Antonio A Menéndez J Carlos JC León Rafael R
Scientific reports 20170331
The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have emerged as key targets for the treatment of Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. These pathological hallmarks are closely related to the over-activity of the enzyme GSK3β and the downregulation of the defense pathway Nrf2-EpRE observed in AD patients. Herein, we report the synthesis and pharmacological evaluation of a new family of multitarget 2,4-dihydropyrano[2,3-c]p ...[more]