Ontology highlight
ABSTRACT:
SUBMITTER: Roberts EW
PROVIDER: S-EPMC5374862 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Roberts Edward W EW Broz Miranda L ML Binnewies Mikhail M Headley Mark B MB Nelson Amanda E AE Wolf Denise M DM Kaisho Tsuneyasu T Bogunovic Dusan D Bhardwaj Nina N Krummel Matthew F MF
Cancer cell 20160714 2
Intratumoral dendritic cells (DC) bearing CD103 in mice or CD141 in humans drive intratumoral CD8(+) T cell activation. Using multiple strategies, we identified a critical role for these DC in trafficking tumor antigen to lymph nodes (LN), resulting in both direct CD8(+) T cell stimulation and antigen hand-off to resident myeloid cells. These effects all required CCR7. Live imaging demonstrated direct presentation to T cells in LN, and CCR7 loss specifically in these cells resulted in defective ...[more]