Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen.
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ABSTRACT:
SUBMITTER: Markov GV
PROVIDER: S-EPMC5375646 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogen.
Markov Gabriel V GV Gutierrez-Mazariegos Juliana J Pitrat Delphine D Billas Isabelle M L IML Bonneton François F Moras Dino D Hasserodt Jens J Lecointre Guillaume G Laudet Vincent V
Science advances 20170331 3
The origin of ancient ligand/receptor couples is often analyzed via reconstruction of ancient receptors and, when ligands are products of metabolic pathways, they are not supposed to evolve. However, because metabolic pathways are inherited by descent with modification, their structure can be compared using cladistic analysis. Using this approach, we studied the evolution of steroid hormones. We show that side-chain cleavage is common to most vertebrate steroids, whereas aromatization was co-opt ...[more]
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