Ontology highlight
ABSTRACT:
SUBMITTER: Barnash KD
PROVIDER: S-EPMC5376495 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Barnash Kimberly D KD The Juliana J Norris-Drouin Jacqueline L JL Cholensky Stephanie H SH Worley Beau M BM Li Fengling F Stuckey Jacob I JI Brown Peter J PJ Vedadi Masoud M Arrowsmith Cheryl H CH Frye Stephen V SV James Lindsey I LI
ACS combinatorial science 20170222 3
The function of EED within polycomb repressive complex 2 (PRC2) is mediated by a complex network of protein-protein interactions. Allosteric activation of PRC2 by binding of methylated proteins to the embryonic ectoderm development (EED) aromatic cage is essential for full catalytic activity, but details of this regulation are not fully understood. EED's recognition of the product of PRC2 activity, histone H3 lysine 27 trimethylation (H3K27me3), stimulates PRC2 methyltransferase activity at adja ...[more]