Ontology highlight
ABSTRACT:
SUBMITTER: Martorana D
PROVIDER: S-EPMC5376573 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Martorana Davide D Bonatti Francesco F Mozzoni Paola P Vaglio Augusto A Percesepe Antonio A
Frontiers in immunology 20170403
Autoinflammatory diseases (AIDs) are a genetically heterogeneous group of diseases caused by mutations of genes encoding proteins, which play a pivotal role in the regulation of the inflammatory response. In the pathogenesis of AIDs, the role of the genetic background is triggered by environmental factors through the modulation of the innate immune system. Monogenic AIDs are characterized by Mendelian inheritance and are caused by highly penetrant genetic variants in single genes. During the las ...[more]