T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility.
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SUBMITTER: Ghassibe-Sabbagh M
PROVIDER: S-EPMC5376673 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
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T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility.
Ghassibe-Sabbagh Michella M Haber Marc M Salloum Angelique K AK Al-Sarraj Yasser Y Akle Yasmine Y Hirbli Kamal K Romanos Jihane J Mouzaya Francis F Gauguier Dominique D Platt Daniel E DE El-Shanti Hatem H Zalloua Pierre A PA
Scientific reports 20141208
Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, wit ...[more]
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