Ontology highlight
ABSTRACT:
SUBMITTER: Kretzmann JA
PROVIDER: S-EPMC5376716 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Chemical science 20170127 4
Tools for editing the genome and epigenome have revolutionised the field of molecular biology and represent a new frontier in targeted therapeutic intervention. Although efficiencies and specificities of genome editing technologies have improved with the development of TALEs and CRISPR platforms, intracellular delivery of these larger constructs still remains a challenge using existing delivery agents. Viral vectors, including lentiviruses and adeno-associated viruses, as well as some non-viral ...[more]