Unknown

Dataset Information

0

Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia.


ABSTRACT: Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.

SUBMITTER: Gunaletchumy SP 

PROVIDER: S-EPMC5377019 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Helicobacter pylori genetic diversity and gastro-duodenal diseases in Malaysia.

Gunaletchumy Selva Perumal SP   Seevasant Indran I   Tan Mun Hua MH   Croft Laurence J LJ   Croft Laurence J LJ   Mitchell Hazel M HM   Goh Khean Lee KL   Loke Mun Fai MF   Vadivelu Jamuna J  

Scientific reports 20141211


Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori  ...[more]

Similar Datasets

| S-EPMC4356907 | biostudies-literature
2001-07-25 | GSE6 | GEO
2001-07-25 | E-GEOD-6 | biostudies-arrayexpress
| S-EPMC3130061 | biostudies-literature
| S-EPMC179045 | biostudies-other
| S-EPMC18976 | biostudies-literature
| S-EPMC10290643 | biostudies-literature
| S-EPMC6521506 | biostudies-literature
| S-EPMC2583950 | biostudies-literature
| S-EPMC152634 | biostudies-literature