Ontology highlight
ABSTRACT:
SUBMITTER: Hammink R
PROVIDER: S-EPMC5377267 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Hammink Roel R Mandal Subhra S Eggermont Loek J LJ Nooteboom Marco M Willems Peter H G M PH Tel Jurjen J Rowan Alan E AE Figdor Carl G CG Blank Kerstin G KG
ACS omega 20170316 3
Artificial antigen-presenting cells (aAPCs) have recently gained a lot of attention. They efficiently activate T cells and serve as powerful replacements for dendritic cells in cancer immunotherapy. Focusing on a specific class of polymer-based aAPCs, so-called synthetic dendritic cells (sDCs), we have investigated the importance of multivalent binding on T-cell activation. Using antibody-functionalized sDCs, we have tested the influence of polymer length and antibody density. Increasing the mul ...[more]