Ontology highlight
ABSTRACT:
SUBMITTER: Hur W
PROVIDER: S-EPMC5377334 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Hur Wonhee W Ryu Jae Yong JY Kim Hyun Uk HU Hong Sung Woo SW Lee Eun Byul EB Lee Sang Yup SY Yoon Seung Kew SK
Scientific reports 20170403
Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and compared the global metabolic phenotype between LCSCs and non-LCSCs using transcriptome and metabolome data. We also reconstructed genome-scale metabolic models (GEMs) for LCSC and non- ...[more]