Dataset Information

A high-resolution LC-MS-based secondary metabolite fingerprint database of marine bacteria.

ABSTRACT: Marine bacteria are the most widely distributed organisms in the ocean environment and produce a wide variety of secondary metabolites. However, traditional screening for bioactive natural compounds is greatly hindered by the lack of a systematic way of cataloguing the chemical profiles of bacterial strains found in nature. Here we present a chemical fingerprint database of marine bacteria based on their secondary metabolite profiles, acquired by high-resolution LC-MS. Till now, 1,430 bacterial strains spanning 168 known species collected from different marine environments were cultured and profiled. Using this database, we demonstrated that secondary metabolite profile similarity is approximately, but not always, correlated with taxonomical similarity. We also validated the ability of this database to find species-specific metabolites, as well as to discover known bioactive compounds from previously unknown sources. An online interface to this database, as well as the accompanying software, is provided freely for the community to use.

SUBMITTER: Lu L

PROVIDER: S-EPMC5377448 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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A high-resolution LC-MS-based secondary metabolite fingerprint database of marine bacteria.

Lu Liang L Wang Jijie J Xu Ying Y Wang Kailing K Hu Yingwei Y Tian Renmao R Yang Bo B Lai Qiliang Q Li Yongxin Y Zhang Weipeng W Shao Zongze Z Lam Henry H Qian Pei-Yuan PY

Scientific reports 20141009

Marine bacteria are the most widely distributed organisms in the ocean environment and produce a wide variety of secondary metabolites. However, traditional screening for bioactive natural compounds is greatly hindered by the lack of a systematic way of cataloguing the chemical profiles of bacterial strains found in nature. Here we present a chemical fingerprint database of marine bacteria based on their secondary metabolite profiles, acquired by high-resolution LC-MS. Till now, 1,430 bacterial ...[more]

PMID: 25298017

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Dataset Information

A high-resolution LC-MS-based secondary metabolite fingerprint database of marine bacteria.

Publications

A high-resolution LC-MS-based secondary metabolite fingerprint database of marine bacteria.

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