Ontology highlight
ABSTRACT:
SUBMITTER: Luo GF
PROVIDER: S-EPMC5377537 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Luo Guo-Feng GF Chen Wei-Hai WH Liu Yun Y Lei Qi Q Zhuo Ren-Xi RX Zhang Xian-Zheng XZ
Scientific reports 20140814
A multifunctional enveloped nanodevice based on mesoporous silica nanoparticle (MSN) was delicately designed for subcellular co-delivery of drug and therapeutic peptide to tumor cells. Mesoporous silica MCM-41 nanoparticles were used as the core for loading antineoplastic drug topotecan (TPT). The surface of nanoparticles was decorated with mitochondria-targeted therapeutic agent (Tpep) containing triphenylphosphonium (TPP) and antibiotic peptide (KLAKLAK)2 via disulfide linkage, followed by coa ...[more]