Ontology highlight
ABSTRACT:
SUBMITTER: Zhang G
PROVIDER: S-EPMC5377910 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Zhang Guolin G Scarborough Hannah H Kim Jihye J Rozhok Andrii I AI Chen Yian Ann YA Zhang Xiaohui X Song Lanxi L Bai Yun Y Fang Bin B Liu Richard Z RZ Koomen John J Tan Aik Choon AC Degregori James J Haura Eric B EB
Science signaling 20161018 450
Patients with lung cancers harboring anaplastic lymphoma kinase (ALK) gene fusions benefit from treatment with ALK inhibitors, but acquired resistance inevitably arises. A better understanding of proximal ALK signaling mechanisms may identify sensitizers to ALK inhibitors that disrupt the balance between prosurvival and proapoptotic effector signals. Using affinity purification coupled with mass spectrometry in an ALK fusion lung cancer cell line (H3122), we generated an ALK signaling network an ...[more]