Elevated Rate of Genome Rearrangements in Radiation-Resistant Bacteria.

ABSTRACT: A number of bacterial, archaeal, and eukaryotic species are known for their resistance to ionizing radiation. One of the challenges these species face is a potent environmental source of DNA double-strand breaks, potential drivers of genome structure evolution. Efficient and accurate DNA double-strand break repair systems have been demonstrated in several unrelated radiation-resistant species and are putative adaptations to the DNA damaging environment. Such adaptations are expected to compensate for the genome-destabilizing effect of environmental DNA damage and may be expected to result in a more conserved gene order in radiation-resistant species. However, here we show that rates of genome rearrangements, measured as loss of gene order conservation with time, are higher in radiation-res

SUBMITTER: Repar J 

PROVIDER: S-EPMC5378121 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature