Cell-size distribution in epithelial tissue formation and homeostasis.

ABSTRACT: How cell growth and proliferation are orchestrated in living tissues to achieve a given biological function is a central problem in biology. During development, tissue regeneration and homeostasis, cell proliferation must be coordinated by spatial cues in order for cells to attain the correct size and shape. Biological tissues also feature a notable homogeneity of cell size, which, in specific cases, represents a physiological need. Here, we study the temporal evolution of the cell-size distribution by applying the theory of kinetic fragmentation to tissue development and homeostasis. Our theory predicts self-similar probability density function (PDF) of cell size and explains how division times and redistribution ensure cell size homogeneity across the tissue. Theoretical predictions and

SUBMITTER: Puliafito A 

PROVIDER: S-EPMC5378146 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature