Whole transcriptome sequencing identifies increased CXCR2 expression in PNH granulocytes.
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ABSTRACT:
SUBMITTER: Hosokawa K
PROVIDER: S-EPMC5378616 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Whole transcriptome sequencing identifies increased CXCR2 expression in PNH granulocytes.
Hosokawa Kohei K Kajigaya Sachiko S Keyvanfar Keyvan K Qiao Wangmin W Xie Yanling Y Biancotto Angelique A Townsley Danielle M DM Feng Xingmin X Young Neal S NS
British journal of haematology 20170201 1
The aetiology of paroxysmal nocturnal haemoglobinuria (PNH) is a somatic mutation in the X-linked phosphatidylinositol glycan class A gene (PIGA), resulting in global deficiency of glycosyl phosphatidylinositol-anchored proteins (GPI-APs). This study applied RNA-sequencing to examine functional effects of the PIGA mutation in human granulocytes. CXCR2 expression was increased in GPI-AP<sup>-</sup> compared to GPI-AP<sup>+</sup> granulocytes. Macrophage migration inhibitory factor, a CXCR2 agonis ...[more]
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