Ontology highlight
ABSTRACT:
SUBMITTER: Berghoff AS
PROVIDER: S-EPMC5378732 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Current treatment options in neurology 20170401 4
<h4>Opinion statement</h4>Brain metastases are a major clinical challenge occurring in up to 60% of patients suffering from metastatic melanoma. They cause significant clinical symptoms and impair the overall survival prognosis. The introduction of targeted therapies including BRAF and MEK inhibitors as well as CTLA-4 and PD-1 axis targeting immune checkpoint inhibitors have dramatically improved the treatment and prognosis of patients with extracranial metastatic melanoma. Although, similar res ...[more]