Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC5378956 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Zhang Zhentao Z Obianyo Obiamaka O Dall Elfriede E Du Yuhong Y Fu Haian H Liu Xia X Kang Seong Su SS Song Mingke M Yu Shan-Ping SP Cabrele Chiara C Schubert Mario M Li Xiaoguang X Wang Jian-Zhi JZ Brandstetter Hans H Ye Keqiang K
Nature communications 20170327
δ-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the amyloid-β and tau pathology in Alzheimer's disease (AD). Here we report the therapeutic effect of an orally bioactive and brain permeable δ-secretase inhibitor in mouse models of AD. We performed a high-throughput screen and identified a non-toxic and selective δ-secretase inhibitor, termed compound 11, that specifically ...[more]