Ontology highlight
ABSTRACT:
SUBMITTER: Cai W
PROVIDER: S-EPMC5378997 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cai Weikang W Sakaguchi Masaji M Kleinridders Andre A Gonzalez-Del Pino Gonzalo G Dreyfuss Jonathan M JM O'Neill Brian T BT Ramirez Alfred K AK Pan Hui H Winnay Jonathon N JN Boucher Jeremie J Eck Michael J MJ Kahn C Ronald CR
Nature communications 20170327
Despite a high degree of homology, insulin receptor (IR) and IGF-1 receptor (IGF1R) mediate distinct cellular and physiological functions. Here, we demonstrate how domain differences between IR and IGF1R contribute to the distinct functions of these receptors using chimeric and site-mutated receptors. Receptors with the intracellular domain of IGF1R show increased activation of Shc and Gab-1 and more potent regulation of genes involved in proliferation, corresponding to their higher mitogenic ac ...[more]