Ontology highlight
ABSTRACT:
SUBMITTER: Botella L
PROVIDER: S-EPMC5379054 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature communications 20170328
Rifampicin, which inhibits bacterial RNA polymerase, provides one of the most effective treatments for tuberculosis. Inhibition of the transcription termination factor Rho is used to treat some bacterial infections, but its importance varies across bacteria. Here we show that Rho of Mycobacterium tuberculosis functions to both define the 3' ends of mRNAs and silence substantial fragments of the genome. Brief inactivation of Rho affects over 500 transcripts enriched for genes of foreign DNA eleme ...[more]