Ontology highlight
ABSTRACT:
SUBMITTER: Afshari NA
PROVIDER: S-EPMC5379100 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature communications 20170330
The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial corneal dystrophy (FECD), the most prevalent corneal disorder requiring transplantation, we conducted a genome-wide association study (GWAS) on 1,404 FECD cases and 2,564 controls of European ancestry, followed by replication and meta-analysis, for a total of 2,075 cases and 3,342 controls. We identify three nov ...[more]