Ontology highlight
ABSTRACT:
SUBMITTER: Afshari NA
PROVIDER: S-EPMC5379100 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Afshari Natalie A NA Igo Robert P RP Morris Nathan J NJ Stambolian Dwight D Sharma Shiwani S Pulagam V Lakshmi VL Dunn Steven S Stamler John F JF Truitt Barbara J BJ Rimmler Jacqueline J Kuot Abraham A Croasdale Christopher R CR Qin Xuejun X Burdon Kathryn P KP Riazuddin S Amer SA Mills Richard R Klebe Sonja S Minear Mollie A MA Zhao Jiagang J Balajonda Elmer E Rosenwasser George O GO Baratz Keith H KH Mootha V Vinod VV Patel Sanjay V SV Gregory Simon G SG Bailey-Wilson Joan E JE Price Marianne O MO Price Francis W FW Craig Jamie E JE Fingert John H JH Gottsch John D JD Aldave Anthony J AJ Klintworth Gordon K GK Lass Jonathan H JH Li Yi-Ju YJ Iyengar Sudha K SK
Nature communications 20170330
The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial corneal dystrophy (FECD), the most prevalent corneal disorder requiring transplantation, we conducted a genome-wide association study (GWAS) on 1,404 FECD cases and 2,564 controls of European ancestry, followed by replication and meta-analysis, for a total of 2,075 cases and 3,342 controls. We identify three nov ...[more]