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Non-malignant respiratory disease among workers in industries using styrene-A review of the evidence.

ABSTRACT: Asthma and obliterative bronchiolitis (OB) cases have occurred among styrene-exposed workers. We aimed to investigate styrene as a risk factor for non-malignant respiratory disease (NMRD).From a literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (i.e., strong, intermediate, suggestive, none) between styrene exposure and NMRD-related morbidity and mortality.We analyzed 55 articles and two unpublished case reports. Ten OB cases and eight asthma cases were identified. Six (75%) asthma cases had abnormal styrene inhalation challenges. Thirteen (87%) of 15 cross-sectional studies and 12 (50%) of 24 mortality studies provided at least suggestive evidence that styrene was associated with NMRD-related morbidity or mortality. Six (66%) of nine mortality studies assessing chronic obstructive pulmonary disease-related mortality indicated excess mortality.Available evidence suggests styrene exposure is a potential risk factor for NMRD. Additional studies of styrene-exposed workers are warranted. Am. J. Ind. Med. 60:163-180, 2017. © 2016 Wiley Periodicals, Inc.

SUBMITTER: Nett RJ

PROVIDER: S-EPMC5379121 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Non-malignant respiratory disease among workers in industries using styrene-A review of the evidence.

Nett Randall J RJ Cox-Ganser Jean M JM Hubbs Ann F AF Ruder Avima M AM Cummings Kristin J KJ Huang Yuh-Chin T YT Kreiss Kathleen K

American journal of industrial medicine 20170201 2

<h4>Background</h4>Asthma and obliterative bronchiolitis (OB) cases have occurred among styrene-exposed workers. We aimed to investigate styrene as a risk factor for non-malignant respiratory disease (NMRD).<h4>Methods</h4>From a literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (i.e., strong, intermediate, suggestive, none) between styrene exposure and NMRD-related morbidity and mortality.<h4>Results ...[more]

PMID: 28079275

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Non-malignant respiratory disease among workers in industries using styrene-A review of the evidence.

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Non-malignant respiratory disease among workers in industries using styrene-A review of the evidence.

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