Gestational diabetes mellitus may be associated with increased risk of breast cancer.

ABSTRACT:

Background

Although a positive association between type 2 diabetes and breast cancer has been reported, an association with gestational diabetes mellitus (GDM) is less clear.

Methods

The Sister Study enroled 50 884 women aged 35-74 years, from 2003 through 2009. Cox proportional hazards models were used to estimate breast cancer risk in relation to GDM.

Results

Ever having GDM was not associated with breast cancer overall (hazards ratio (HR)=1.10, 95% confidence interval (CI)=0.88-1.36), but there was a suggestive association between ever having a GDM pregnancy and oestrogen receptor (ER) -negative breast cancer (HR=1.73, 95% CI=0.98-3.06). However, having 2 or more GDM pregnancies was associated with overall breast cancer risk 1.68 (95% CI=1.15-2.44) and with ER-posi

SUBMITTER: Park YM 

PROVIDER: S-EPMC5379146 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature