Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC5379632 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Li Gang G Ye Zhisheng Z Shi Cheng C Sun Ling L Han Min M Zhuang Yuan Y Xu Tian T Zhao Shimin S Wu Xiaohui X
Scientific reports 20170404
Epidermal homeostasis under normal and healing conditions are critical for the physical and functional maintenance of the skin barrier. It requires a proper balance between keratinocyte proliferation and differentiation under genetic and epigenetic regulations. Here we show that mice carrying a hypomorphic mutation of the histone methyltransferase Ash1l [(absent, small, or homeotic)-like (Drosophila)] develop epidermal hyperplasia and impaired epidermal stratification upon aging. In adult mutant ...[more]