Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC5379745 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Liu Zhida Z Zhou Chang C Qin Yan Y Wang Zihao Z Wang Luyao L Wei Xiuli X Zhou Yinjian Y Li Qicheng Q Zhou Hang H Wang Wenjun W Fu Yang-Xin YX Zhu Mingzhao M Liang Wei W
Cell discovery 20170404
Although re-activating cytotoxic T-cell (CTLs) response inside tumor tissues by checkpoint blockade has demonstrated great success in tumor immunotherapy, active induction of efficient endogenous CTL response by therapeutic vaccines has been largely hampered by inefficient cytosolic delivery of antigens and coordinated activation of dendritic cells (DCs) in lymph nodes. Here we show that polyethylene glycol-phosphatidylethanolamine (PEG-PE) micelles transform soluble peptides into α-helix to ena ...[more]