Ontology highlight
ABSTRACT:
SUBMITTER: Hu MM
PROVIDER: S-EPMC5379974 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Hu Ming-Ming MM Liao Chen-Yang CY Yang Qing Q Xie Xue-Qin XQ Shu Hong-Bing HB
The Journal of experimental medicine 20170301 4
Sensing of viral RNA by the cytosolic receptors RIG-I and melanoma differentiation-associated gene 5 (MDA5) leads to innate antiviral response. How RIG-I and MDA5 are dynamically regulated in innate antiviral response is not well understood. Here, we show that TRIM38 positively regulates MDA5- and RIG-I-mediated induction of downstream genes and acts as a SUMO E3 ligase for their dynamic sumoylation at K43/K865 and K96/K888, respectively, before and after viral infection. The sumoylation of MDA5 ...[more]