Ontology highlight
ABSTRACT:
SUBMITTER: Diny NL
PROVIDER: S-EPMC5379983 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Diny Nicola L NL Baldeviano G Christian GC Talor Monica V MV Barin Jobert G JG Ong SuFey S Bedja Djahida D Hays Allison G AG Gilotra Nisha A NA Coppens Isabelle I Rose Noel R NR Čiháková Daniela D
The Journal of experimental medicine 20170316 4
Inflammatory dilated cardiomyopathy (DCMi) is a major cause of heart failure in children and young adults. DCMi develops in up to 30% of myocarditis patients, but the mechanisms involved in disease progression are poorly understood. Patients with eosinophilia frequently develop cardiomyopathies. In this study, we used the experimental autoimmune myocarditis (EAM) model to determine the role of eosinophils in myocarditis and DCMi. Eosinophils were dispensable for myocarditis induction but were re ...[more]