Ontology highlight
ABSTRACT:
SUBMITTER: Dabrowski-Tumanski P
PROVIDER: S-EPMC5380043 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Dabrowski-Tumanski Pawel P Sulkowska Joanna I JI
Proceedings of the National Academy of Sciences of the United States of America 20170309 13
Twenty years after their discovery, knots in proteins are now quite well understood. They are believed to be functionally advantageous and provide extra stability to protein chains. In this work, we go one step further and search for links-entangled structures, more complex than knots, which consist of several components. We derive conditions that proteins need to meet to be able to form links. We search through the entire Protein Data Bank and identify several sequentially nonhomologous chains ...[more]