Ontology highlight
ABSTRACT:
SUBMITTER: Gulati S
PROVIDER: S-EPMC5380078 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170313 13
Vertebrate rhodopsin (Rh) contains 11-<i>cis</i>-retinal as a chromophore to convert light energy into visual signals. On absorption of light, 11-<i>cis</i>-retinal is isomerized to all-<i>trans</i>-retinal, constituting a one-way reaction that activates transducin (G<sub>t</sub>) followed by chromophore release. Here we report that bovine Rh, regenerated instead with a six-carbon-ring retinal chromophore featuring a C<sup>11</sup>=C<sup>12</sup> double bond locked in its <i>cis</i> conformation ...[more]