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The effect of music performance on the transcriptome of professional musicians.

ABSTRACT: Music performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated that the brains of professional musicians and non-musicians differ structurally and functionally and that musical training enhances cognition. However, the molecules and molecular mechanisms involved in music performance remain largely unexplored. Here, we investigated the effect of music performance on the genome-wide peripheral blood transcriptome of professional musicians by analyzing the transcriptional responses after a 2-hr concert performance and after a 'music-free' control session. The up-regulated genes were found to affect dopaminergic neurotransmission, motor behavior, neuronal plasticity, and neurocognitive functions including learning and memory. Particularly, candidate genes such as SNCA, FOS and DUSP1 that are involved in song perception and production in songbirds, were identified, suggesting an evolutionary conservation in biological processes related to sound perception/production. Additionally, modulation of genes related to calcium ion homeostasis, iron ion homeostasis, glutathione metabolism, and several neuropsychiatric and neurodegenerative diseases implied that music performance may affect the biological pathways that are otherwise essential for the proper maintenance of neuronal function and survival. For the first time, this study provides evidence for the candidate genes and molecular mechanisms underlying music performance.

SUBMITTER: Kanduri C

PROVIDER: S-EPMC5380155 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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The effect of music performance on the transcriptome of professional musicians.

Kanduri Chakravarthi C Kuusi Tuire T Ahvenainen Minna M Philips Anju K AK Lähdesmäki Harri H Järvelä Irma I

Scientific reports 20150325

Music performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated that the brains of professional musicians and non-musicians differ structurally and functionally and that musical training enhances cognition. However, the molecules and molecular mechanisms involved in music performance remain largely unexplored. Here, we investigated the effect of music performance ...[more]

PMID: 25806429

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Project description:Musical training and performance require precise integration of multisensory and motor centres of the human brain and can be regarded as an epigenetic modifier of brain functions. Numerous studies have identified structural and functional differences between the brains of musicians and non-musicians and superior cognitive functions in musicians. Recently, music-listening and performance has also been shown to affect the regulation of several genes, many of which were identified in songbird singing. MicroRNAs affect gene regulation and studying their expression may give new insights into the epigenetic effect of music. Here, we studied the effect of 2 hours of classical music-performance on the peripheral blood microRNA expressions in professional musicians with respect to a control activity without music for the same duration. As detecting transcriptomic changes in the functional human brain remains a challenge for geneticists, we used peripheral blood to study music-performance induced microRNA changes and interpreted the results in terms of potential effects on brain function, based on the current knowledge about the microRNA function in blood and brain. We identified significant (FDR <0.05) up-regulation of five microRNAs; hsa-miR-3909, hsa-miR-30d-5p, hsa-miR-92a-3p, hsa-miR-222-3p and hsa-miR-30a-5p; and down-regulation of two microRNAs; hsa-miR-6803-3p and hsa-miR-1249-3p. hsa-miR-222-3p and hsa-miR-92a-3p putatively target FOXP2, which was found down-regulated by microRNA regulation in songbird singing. miR-30d and miR-222 corroborate microRNA response observed in zebra finch song-listening/learning. miR-222 is induced by ERK cascade, which is important for memory formation, motor neuron functions and neuronal plasticity. miR-222 is also activated by FOSL1, an immediate early gene from the FOS family of transcriptional regulators which are activated by auditory-motor stimuli. miR-222 and miR-92 promote neurite outgrowth by negatively regulating the neuronal growth inhibitor, PTEN, and by activating CREB expression and phosphorylation. The up-regulation of microRNAs previously found to be regulators of auditory and nervous system functions (miR-30d, miR-92a and miR-222) is indicative of the sensory perception processes associated with music-performance. Akt signalling pathway which has roles in cell survival, cell differentiation, activation of CREB signalling and dopamine transmission was one of the functions regulated by the up-regulated microRNAs; in accordance with functions identified from songbird learning. The up-regulated microRNAs were also found to be regulators of apoptosis, suggesting repression of apoptotic mechanisms in connection with music-performance. Furthermore, comparative analyses of the target genes of differentially expressed microRNAs with that of the song-responsive microRNAs in songbirds suggest convergent regulatory mechanisms underlying auditory perception.

Project description:In audiovisual music perception, visual information from a musical instrument being played is available prior to the onset of the corresponding musical sound and consequently allows a perceiver to form a prediction about the upcoming audio music. This prediction in audiovisual music perception, compared to auditory music perception, leads to lower N1 and P2 amplitudes and latencies. Although previous research suggests that audiovisual experience, such as previous musical experience may enhance this prediction, a remaining question is to what extent musical experience modifies N1 and P2 amplitudes and latencies. Furthermore, corresponding event-related phase modulations quantified as inter-trial phase coherence (ITPC) have not previously been reported for audiovisual music perception. In the current study, audio video recordings of a keyboard key being played were presented to musicians and non-musicians in audio only (AO), video only (VO), and audiovisual (AV) conditions. With predictive movements from playing the keyboard isolated from AV music perception (AV-VO), the current findings demonstrated that, compared to the AO condition, both groups had a similar decrease in N1 amplitude and latency, and P2 amplitude, along with correspondingly lower ITPC values in the delta, theta, and alpha frequency bands. However, while musicians showed lower ITPC values in the beta-band in AV-VO compared to the AO, non-musicians did not show this pattern. Findings indicate that AV perception may be broadly correlated with auditory perception, and differences between musicians and non-musicians further indicate musical experience to be a specific factor influencing AV perception. Predicting an upcoming sound in AV music perception may involve visual predictory processes, as well as beta-band oscillations, which may be influenced by years of musical training. This study highlights possible interconnectivity in AV perception as well as potential modulation with experience.

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The effect of music performance on the transcriptome of professional musicians.

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The effect of music performance on the transcriptome of professional musicians.

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