Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation.

ABSTRACT:

Background

The safety and efficacy of aerobic exercise in heart failure (HF) patients with atrial fibrillation (AF) has not been well evaluated.

Objectives

This study examined whether outcomes with exercise training in HF vary according to AF status.

Methods

HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) randomized 2,331 ambulatory HF patients with ejection fraction ≤35% to exercise training or usual care. We examined clinical characteristics and outcomes (mortality/hospitalization) by baseline AF status (past history of AF or AF on baseline electrocardiogram vs. no AF) using adjusted Cox models and explored an interaction with exercise training. We assessed post-randomization AF events diagnosed via hospitalizations for AF a

SUBMITTER: Luo N 

PROVIDER: S-EPMC5380238 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature