Ontology highlight
ABSTRACT:
SUBMITTER: Viladomiu M
PROVIDER: S-EPMC5380565 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Viladomiu Monica M Bassaganya-Riera Josep J Tubau-Juni Nuria N Kronsteiner Barbara B Leber Andrew A Philipson Casandra W CW Zoccoli-Rodriguez Victoria V Hontecillas Raquel R
Journal of immunology (Baltimore, Md. : 1950) 20170306 8
<i>Helicobacter pylori</i>, the dominant member of the human gastric microbiota, elicits immunoregulatory responses implicated in protective versus pathological outcomes. To evaluate the role of macrophages during infection, we employed a system with a shifted proinflammatory macrophage phenotype by deleting PPARγ in myeloid cells and found a 5- to 10-fold decrease in gastric bacterial loads. Higher levels of colonization in wild-type mice were associated with increased presence of mononuclear p ...[more]