Ontology highlight
ABSTRACT:
SUBMITTER: Yang G
PROVIDER: S-EPMC5381011 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yang Guang G Weng Xinyu X Zhao Yuhao Y Zhang Xinjian X Hu Yuanping Y Dai Xin X Liang Peng P Wang Peng P Ma LeiLei L Sun Xiaolei X Hou Lei L Xu Huihui H Fang Mingming M Li Yuehua Y Jenuwein Thomas T Xu Yong Y Sun Aijun A
Nature communications 20170331
Myocardial infarction (MI) dampens heart function and poses a great health risk. The class III deacetylase sirtuin 1 (SIRT1) is known to confer cardioprotection. SIRT1 expression is downregulated in the heart by a number of stress stimuli that collectively drive the pathogenesis of MI, although the underlying mechanism remains largely obscure. Here we show that in primary rat neonatal ventricular myocytes (NRVMs), ischaemic or oxidative stress leads to a rapid upregulation of SUV39H, the mammali ...[more]