Dataset Information

Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort.

ABSTRACT:

Background

The lipid and glucose metabolisms are postulated as possible intermediary mechanisms in linking obesity and breast cancer (BC). Links between serum lipid and glucose biomarkers and BC risk has been observed in the Swedish Apolipoprotein MORtality RISk (AMORIS) cohort. We conducted a follow-up analysis including information on tumour characteristics.

Methods

One thousand eight hundred twenty-four women diagnosed with BC, with serum biomarker levels of glucose, triglycerides, cholesterol (total, HDL, and LDL), and apolipoproteins A-1 and B recorded in a routine health check at baseline were included. BC severity was split into categories (good, moderate, and poor prognosis) based on ER status, TNM stage, and age at diagnosis. Proportional odds models were used to obtain odds ratios (ORs) and 95% confidence intervals (CI), with the interval time between baseline measurement and BC diagnosis accounted for.

Results

Serum glucose and the ApoB/ApoA-1 ratio showed a non-statistically significant positive association with BC severity (proportional OR: 1.25 (95%CI: 0.92-1.70) for glucose (ConclusionsDespite the size and detail of data in AMORIS, we only found a modest positive association between serum levels of glucose, apoB/ApoA-1 and BC severity, suggesting that these factors are not the main players in linking obesity and BC aggressiveness.

SUBMITTER: Melvin JC

PROVIDER: S-EPMC5381045 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Publications

Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort.

Melvin Jennifer C JC Garmo Hans H Holmberg Lars L Hammar Niklas N Walldius Göran G Jungner Ingmar I Lambe Mats M Van Hemelrijck Mieke M

BMC cancer 20170404 1

<h4>Background</h4>The lipid and glucose metabolisms are postulated as possible intermediary mechanisms in linking obesity and breast cancer (BC). Links between serum lipid and glucose biomarkers and BC risk has been observed in the Swedish Apolipoprotein MORtality RISk (AMORIS) cohort. We conducted a follow-up analysis including information on tumour characteristics.<h4>Methods</h4>One thousand eight hundred twenty-four women diagnosed with BC, with serum biomarker levels of glucose, triglyceri ...[more]

PMID: 28376727

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Dataset Information

Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort.

Background

Methods

Results

Publications

Glucose and lipoprotein biomarkers and breast cancer severity using data from the Swedish AMORIS cohort.

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