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Cancer immunotherapies targeting the PD-1 signaling pathway.

ABSTRACT: Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to these new immunotherapies has led to intensified research on combination therapies and predictive biomarkers. Here we summarize the development of PD-1-blockade immunotherapy and current issues in its clinical use.

SUBMITTER: Iwai Y

PROVIDER: S-EPMC5381059 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Cancer immunotherapies targeting the PD-1 signaling pathway.

Iwai Yoshiko Y Hamanishi Junzo J Chamoto Kenji K Honjo Tasuku T

Journal of biomedical science 20170404 1

Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-checkpoint inhibitors take the brakes off the anti-tumor immune responses. Successful clinical trials with PD-1 monoclonal antibodies and other immune-checkpoint inhibitors have opened new avenues in cancer immunology. However, the failure of a large subset of cancer patients to respond to th ...[more]

PMID: 28376884

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