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Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults.

ABSTRACT: BACKGROUND:Resting metabolic rates (RMR) vary across individuals. Understanding the determinants of RMR could provide biological insight into obesity and its metabolic consequences such as type 2 diabetes and cardiovascular diseases. METHODS:The present study measured RMR using reference standard indirect calorimetry and evaluated genetic variations from an exome array in a sample of children and adults (N?=?262) predominantly of African and European ancestry with a wide range of ages (10 - 67 years old) and body mass indices (BMI; 16.9 - 56.3 kg/m2 for adults, 15.1 - 40.6 kg/m2 for children). RESULTS:Single variant analysis for RMR identified suggestive loci on chromosomes 15 (rs74010762, TRPM1, p-value?=?2.7?×?10-6), 1 (rs2358728 and rs2358729, SH3D21, p-values?

SUBMITTER: Hellwege JN

PROVIDER: S-EPMC5381071 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Association of gene coding variation and resting metabolic rate in a multi-ethnic sample of children and adults.

Hellwege Jacklyn N JN Velez Edwards Digna R DR Acra Sari S Chen Kong K Buchowski Maciej S MS Edwards Todd L TL

BMC obesity 20170405

<h4>Background</h4>Resting metabolic rates (RMR) vary across individuals. Understanding the determinants of RMR could provide biological insight into obesity and its metabolic consequences such as type 2 diabetes and cardiovascular diseases.<h4>Methods</h4>The present study measured RMR using reference standard indirect calorimetry and evaluated genetic variations from an exome array in a sample of children and adults (<i>N</i> = 262) predominantly of African and European ancestry with a wide ra ...[more]

PMID: 28417008

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