Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC5381279 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Scientific reports 20140506
The human murine double minute 2 (MDM2) is known as an oncoprotein through inhibiting P53 transcriptional activity and mediating P53 ubiquitination. Therefore, the amplification of MDM2 may attenuate the P53 pathway and promote tumorigenesis. The SNP309 T>G polymorphism (rs2279744), which is located in the intronic promoter of MDM2 gene, was reported to contribute to the increased level of MDM2 protein. In this hospital-based case-control study, which consisted of 573 cases and 588 controls, we ...[more]