Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues.
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ABSTRACT:
SUBMITTER: Guo Z
PROVIDER: S-EPMC5381490 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues.
Guo Zhiyun Z Maki Miranda M Ding Ruofan R Yang Yalan Y Zhang Bao B Xiong Lili L
Scientific reports 20140603
Tissue-specific miRNAs (TS miRNA) specifically expressed in particular tissues play an important role in tissue identity, differentiation and function. However, transcription factor (TF) and TS miRNA regulatory networks across multiple tissues have not been systematically studied. Here, we manually extracted 116 TS miRNAs and systematically investigated the regulatory network of TF-TS miRNA in 12 human tissues. We identified 2,347 TF-TS miRNA regulatory relations and revealed that most TF bindin ...[more]
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