Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease.

ABSTRACT: We sought to determine whether patients with posterior cortical atrophy (PCA) demonstrate a pattern of binding to translocator protein 18 kDa, a marker of microglial activation, that is distinct from that in patients with amnestic presentation of Alzheimer's disease (AD). Eleven PCA patients, 11 amnestic AD patients, and 15 age-matched controls underwent positron emission tomography with ¹¹C-PBR28 to measure translocator protein 18 kDa. PCA patients showed greater ¹¹C-PBR28 binding than controls in occipital, posterior parietal, and temporal regions. In contrast, amnestic AD patients showed greater ¹¹C-PBR28 binding in inferior and medial temporal cortex. Increased ¹¹C-PBR28 binding overlapped with reduced cortical volume for both PCA and amnesti

SUBMITTER: Kreisl WC 

PROVIDER: S-EPMC5381519 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature