Ontology highlight
ABSTRACT:
SUBMITTER: Gerstner JR
PROVIDER: S-EPMC5381954 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Science advances 20170405 4
Sleep is found widely in the animal kingdom. Despite this, few conserved molecular pathways that govern sleep across phyla have been described. The mammalian brain-type fatty acid binding protein (Fabp7) is expressed in astrocytes, and its mRNA oscillates in tandem with the sleep-wake cycle. However, the role of FABP7 in regulating sleep remains poorly understood. We found that the missense mutation FABP7.T61M is associated with fragmented sleep in humans. This phenotype was recapitulated in mic ...[more]