Ontology highlight
ABSTRACT:
SUBMITTER: Wu D
PROVIDER: S-EPMC5382129 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Wu Dalei D Rastinejad Fraydoon F
Current opinion in structural biology 20161006
The mammalian basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) transcription factors share common architectural features that include a bHLH DNA-binding domain and tandemly positioned PAS domains. The sixteen members of this family include the hypoxia-inducible factors (HIF-1α and HIF-2α), ARNT (also known as HIF-1β), CLOCK and BMAL1. Most bHLH-PAS proteins have been genetically linked to variety of diseases in humans, including cancers, metabolic syndromes and psychiatric conditions. To function ...[more]