Ontology highlight
ABSTRACT:
SUBMITTER: Pyoria L
PROVIDER: S-EPMC5382274 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Pyöriä Lari L Toppinen Mari M Mäntylä Elina E Hedman Lea L Aaltonen Leena-Maija LM Vihinen-Ranta Maija M Ilmarinen Taru T Söderlund-Venermo Maria M Hedman Klaus K Perdomo Maria F MF
Nature communications 20170404
Parvovirus B19 (B19V) DNA persists lifelong in human tissues, but the cell type harbouring it remains unclear. We here explore B19V DNA distribution in B, T and monocyte cell lineages of recently excised tonsillar tissues from 77 individuals with an age range of 2-69 years. We show that B19V DNA is most frequent and abundant among B cells, and within them we find a B19V genotype that vanished from circulation >40 years ago. Since re-infection or re-activation are unlikely with this virus type, t ...[more]